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The Mid-Atlantic Twin Registry.

Lisa S Anderson1, William T Beverly, Linda A Corey

  • 1Virginia Institute for Psychiatric and Behavioral Genetics, Department of Human Genetics, Virginia Commonwealth University, Richmond, VA 23298-0003, USA. lsanders@hsc.vcu.edu

Twin Research : the Official Journal of the International Society for Twin Studies
|January 23, 2003
PubMed
Summary

The Mid-Atlantic Twin Registry (MATR) provides a diverse cohort of over 51,000 twins for health research. This population-based registry facilitates studies on various conditions, from cardiovascular disease to mental health.

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Area of Science:

  • Epidemiology
  • Biomedical Research
  • Population Science

Background:

  • The Mid-Atlantic Twin Registry (MATR) was established in 1997 by merging registries from Virginia and North Carolina, later expanding to include South Carolina in 1998.
  • It is a population-based registry comprising over 51,000 twins, with approximately 46,000 complete pairs, primarily from birth and school records in three mid-Atlantic states.
  • The registry includes individuals born between 1913 and 2000, with a majority (two-thirds) being adults over 18, averaging 35 years of age.

Purpose of the Study:

  • To establish and maintain a comprehensive twin registry for epidemiological and genetic research.
  • To facilitate research on a wide range of health conditions and developmental factors in twins and their families.
  • To provide a valuable resource for investigators seeking to recruit twin participants for diverse research studies.

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Main Methods:

  • Ascertainment of twin pairs through birth records and school system records in Virginia, North Carolina, and South Carolina.
  • Data collection and management adhering to strict standard operating procedures and a privacy policy to ensure participant confidentiality.
  • Facilitation of research by considering qualified requests from investigators for participant recruitment.

Main Results:

  • The registry currently holds data on over 51,000 individuals, representing more than 170,000 twin pairs born between 1913 and 2000.
  • Participants have engaged in numerous research projects covering general health, cardiovascular disease, mental health (depression, anxiety), neurological conditions (seizures), behavioral development, and more.
  • The registry represents a significant resource for studying genetic and environmental influences on health and disease.

Conclusions:

  • The Mid-Atlantic Twin Registry is a robust and established resource for twin research in the mid-Atlantic region.
  • Its large, diverse cohort and established protocols support a wide array of health-related investigations.
  • The registry plays a crucial role in advancing scientific understanding through twin studies.