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Published on: November 8, 2011
Inhibitory effects of lapachol derivatives on epstein-barr virus activation
Elisa Pérez Sacau1, Ana Estévez-Braun, Angel G Ravelo
1Instituto Universitario de Bio-Orgánica 'Antonio González', Universidad de La Laguna, Avda. Astrofísico Fco. Sánchez No. 2, E-38206, Tenerife, La Laguna, Spain.
Abstract:
Sixteen derivatives (2-17) synthesized from the naphthoquinone lapachol (1), were tested for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), as a test for potential cancer chemopreventive agents. They exhibited a variety of inhibitory activities from very high to moderate, which allow us to suggest structure-activity relationships. Ten of these derivatives are reported for the first time, their structures being thoroughly determined by spectroscopic methods.
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