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Influence of intravenous vitamin E supplementation in cardiac surgery on oxidative stress: a double-blinded,
1Department of Cardiothoracic Anaesthesia and Intensive Care Medicine, University Hospital of Vienna, Waehringer Guertel 18-20, A-1090 Wien, Austria. andrea.lassnigg@univie.ac.at
Background:
I.V. infusions of vitamin E emulsion (all-rac-alpha-tocopherol) may reduce ischaemia-reperfusion injury after elective cardiac surgery.
Methods:
Forty patients participated in a prospective, double-blind, placebo-controlled, randomized trial, receiving either placebo or four doses (270 mg each) of all-rac-alpha-tocopherol between 16 h before and 48 h after surgery. We determined plasma concentrations of vitamin E, vitamin C, malondialdehyde, creatine kinase, troponin I and interleukin 6 and other measures of clinical outcome.
Results:
Infusion of vitamin E caused normalization of vitamin E plasma concentrations during and after surgery, but had no effect on the early increase in malondialdehyde concentration or the decreases in antioxidative capacity and the water-soluble antioxidant vitamin C.
Conclusions:
Normalization of plasma vitamin E concentrations with parenteral vitamin E emulsion does not affect biochemical markers of myocardial injury and does not affect clinical outcome after cardiac surgery.