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Enteroviral meningoencephalitis after anti-CD20 (rituximab) treatment

Pierre Quartier1, Olivier Tournilhac, Christine Archimbaud

  • 1Unité d'Immunologie-Hématologie et Rhumatologie Pédiatrique, Hôpital Necker-Enfants Malades, 75 743 Paris cedex 15, France. quartier@necker.fr

Treatment with the chimeric anti-CD20 monoclonal antibody rituximab induces rapid and long-lasting depletion of circulating B cells. We report the occurrence of enteroviral meningoencephalitis following rituximab therapy in 1 child with immune thrombocytopenia and in 1 adult patient with relapsed B cell lymphoma.

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