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Secondary progressive chronic manganism associated with markedly decreased striatal D2 receptor density
Kirn R Kessler1, Gilbert Wunderlich, Harald Hefter
1Department of Neurology, J.W. Goethe University, Frankfurt-Main, Germany. k.kessler@em.uni-frankfurt.de
Abstract:
We describe a patient with chronic manganism due to intoxication 40 years ago. Whereas previous reports on acute or subacute intoxication have shown no or only small reductions in striatal D2 receptor density, we found markedly decreased D2 receptor density using (18)F-methylspiperone PET in this very late stage of chronic manganism, supporting the hypothesis that manganese intoxication may trigger a neurodegenerative disease process.