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Updated: Sep 27, 2026

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence
Published on: January 7, 2019
Cancer therapy: switching off oncogenes
Franca Pompetti1, Daniela Pilla, Raffaella Giancola
1Section on Molecular Biology, Laboratory of Haematology, Civil Hospital, Pescara-Italy.
Abstract:
Cancer derives from a cell clone that has accumulated genetic and epigenetic changes that influence its phenotype and finally enable it to escape from the normal controls of proliferation. A recent paper shows that, in myc-induced tumours, the inactivation of this oncogene produces the regression of the tumours and the differentiation of the tumour cells into mature osteocytes.1 In addition, a further reactivation of myc in these cells does not restore the malignant phenotype but induces apoptosis. This discovery could lead to an innovative therapeutic strategy.
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