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Structural models for dimerization of G-protein coupled receptors: the opioid receptor homodimers

Marta Filizola1, Harel Weinstein

  • 1Department of Physiology and Biophysics, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA.

Biopolymers
|January 23, 2003
PubMed

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G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
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G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
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