[Expression of CDK4 protein in oral carcinogenesis]
1Department of Oral Medicine, College of Stomatology, West China University of Medical Sciences.
Objective:
To study the expression of cyclin dependent kinase 4(CDK4) protein in oral carcinogenesis.
Methods:
An LSAB immunohistochemistry method was applied to 80 cases of paraffine-fixed tissues to study the expression and distribution of CDK4 in normal oral mucosa, oral premalignant lesion (OPL) and oral squamous cell carcinoma.
Results:
The overexpression of CDK4 protein was observed in the progression of OPL. Meanwhile, a correlation analysis was applied to investigate the relationship between P16 and CDK4 expression, and the result showed that the coefficient of correlation was 0.813, which was statistically significant.
Conclusion:
The overexpression of CDK4 is involved in the progression of OPL, and there is a positive feedback loop between CDK4 and P16.
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