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Updated: Jul 31, 2026

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
Published on: April 13, 2015
[Telomerase hTRT mRNA expression in oral squamous cell carcinogenesis]
Objective:
To investigate the relationship between telomerase hTRT gene expression and malignant development of oral mucosa epithelium.
Methods:
82 cases were detected by in situ hybridization technique for hTRT gene, including 7 cases of normal oral mucosa, 7 cases of hyperplasia lesions, 30 case sof oral precancerous lesions (dysplasia lesion), 8 cases of oral mucosa carcinoma in situ and 30 cases of oral squamous cell carcinomas.
Results:
1. Weaker expression of hTRT mRNA was observed in normal oral mucosa and hyperplasia lesions. Positive cells were present in basal layer and parabasal layer, and hTRT positivity was 21.4% (3 of 14). 2. The expression of hTRT mRNA in the precancerous lesions was gradually strong associated with phenotypic progression and the degree of dysplasia. Positive cell extended to multi-layered epithelium, and hTRT positivity was 46.7% (14 of 30). 3. Strong hTRT mRNA expression was observed in squamous cell carcinoma, and the positivity was 81.6% (31 of 38).
Conclusion:
Telomerase hTRT gene expression is closely related to the malignant degree of oral mucosa, the reactivated telomerase may play a crucial role in the progression of oral cancer.
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