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[Study on mechanical compression regulating the proliferation of rat mandibular condylar chondrocytes in vitro]
Abstract
Objective:
To study the proliferative changes of cultured rat mandibular condylar chondrocytes effected by mechanical compression.
Methods:
Using flow cytometry(FCM) to explore the changes of cellular DNA content and cell cycles of passaged condylar chondrocytes.
Results:
During certain force range (0-207 g/cm2), the proliferation of rat mandibular condylar chondrocytes rose, reaching the maximum after 6-hour application of force. The cellular proliferation went down when the chondrocytes were cultured under continuous pressure for 24 hours.
Conclusion:
The proliferation of rat mandibular condylar chondrocytes increase under certain force and certain period of time, but decreased if the applied pressure is beyond the magnitude.