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[Effects of bite force loss on the expression of IL-6 mRNA in rat periodontium]
Objective:
The aim of this study is to evaluate the expression of IL-6 mRNA in rat periodontal cells under normal bite force and without bite force, and to explain periodontal remodeling from the molecular level.
Methods:
Animal models with normal bite force and without bite force were established by using Wistar rats. In situ hybridization technique was applied to detect changes of IL-6 mRNA expression in rat periodontal tissue.
Results:
Without bite force, the expression level of IL-6 mRNA increased significantly in periodontal cells.
Conclusion:
This study initially investigates the molecular mechanism of periodontal remodeling, and suggests that the histological morphology may be closely related to the mechanical stimulation.
