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[IL-2 gene and cisplatin combined therapy for head and neck squamous cell carcinoma]
1Department of Otolaryngology, First Affiliated Hospital, West China University of Medical Sciences.
Objective:
The objective of this study is to assess the efficacy of IL-2 gene and cisplatin combined therapy on murine HNSCC models.
Methods:
HNSCC tumors were established in murine models. The sizes of tumors were measured before and after combined IL-2 and cisplatin treatment, and the results were evaluated by comparing different single treatment groups and the control IL-2 expression was measured after IL-2 gene transfer. Cytotoxic T-lymphocyte (CTL) and natural killer (NK) assays were also performed.
Results:
HNSCC tumor growth was significantly inhibited following combined IL-2 gene and cisplatin therapy, when compared with that of the control. The levels of IL-2 protein expressions were increased in combined and single IL-2 treated groups. The activities of cytotoxic T-lymphocytes and natural killers in both the combined treatment group and the IL-2 treated group are higher than those of the controlled group.
Conclusion:
Combined IL-2 gene and cisplatin therapy can significantly inhibit HNSCC tumor growth in the murine models, and efficiently induces anti-tumor immune reaction of hosts.
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