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Published on: April 22, 2019
[Impacts of clinicopathologic parameters on lymphatic metastasis of oral squamous cell carcinoma]
Objective:
To evaluate the effects of clinicopathologic parameters on lymphatic metastasis of oral squamous cell carcinoma.
Methods:
One hundred and ninety-three patients who underwent therapy in our department were included in this study. Ten parameters (T and N stages, location, patterns of invasion, thickness, lymphocyte infiltration, karyokinesis count, degrees of differentiation, degrees of cell keratinization and nuclear polymorph) were evaluated to determine their effects on lymphatic metastasis of oral carcinoma using univariate and multivariate analysis.
Results:
By using the univariate analysis, five parameters (T and N stage, pattern and depth of invasion, lymphocyte infiltration) showed significant impacts on pathologic nodal metastasis. From multivariate analysis, however, only patterns of invasion were independent predictors of metastasis. Also, patterns of invasion were the only significant factors that influence the post-operative metastasis besides pattern of neck treatment.
Conclusion:
The pattern of invasion is the most important parameter that influences the metastasis of oral squamous cell carcinoma.
