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Effect of pressure on intracardiac backscatter from microbubbles
1Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030.
Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao
|January 24, 2003
Summary
Acoustic densitometry of albumin microbubbles (Albunex) revealed pressure-dependent backscatter changes during the cardiac cycle. This non-invasive method shows potential for evaluating intracardiac pressure in humans.
Area of Science:
- Biomedical Engineering
- Acoustics
- Cardiology
Background:
- Albumin microbubbles (Albunex) are used in ultrasound imaging.
- Acoustic densitometry measures backscatter properties of microbubbles.
- Cardiac cycle involves dynamic pressure changes within the heart.
Purpose of the Study:
- To evaluate the effect of pressure on Albunex backscatter.
- To analyze cardiac cyclic changes in intracardiac backscatter.
- To assess the feasibility of non-invasive intracardiac pressure evaluation.
Main Methods:
- In vitro analysis using a pulsatile heart model.
- Acoustic densitometry to measure microbubble backscatter.
- In vivo analysis of intracardiac backscatter in healthy subjects.
Main Results:
- Albunex microbubbles compressed in systole and decompressed in diastole, altering backscatter.
- Microbubble concentration affected backscatter intensity but not the pressure-dependent difference.
- The difference in end-diastolic and end-systolic backscatter strongly correlated with end-systolic pressure (r = 0.96).
Conclusions:
- Intracardiac backscatter from albumin microbubbles exhibits cyclic changes related to cardiac pressure.
- Non-invasive evaluation of intracardiac pressure is possible using acoustic densitometry and microbubbles.
- This technique offers a novel approach for hemodynamic monitoring.