[Influence of octadine, reserpine and methyl-dopa on the hemodynamic system]

In experiments set up on rats the influence of octadine (sanotensin), reserpine and methyl-dopa on the basic characteristics of the systemic hemodynamics in persistent renovascular hypertension was studied. The nature of the influence exerted by the above drugs on the systemic hemodynamics of hypertensive rats is shown to depend upon the duration of their action on the organism. The hypotensive effect manifests itself first by reduced cardiac ejection and then by a fall of the total peripheral resistance. It is presumed that the disappearance of the inhibitory action of octadine, reserpine and methyl-dopa on the cardiac ejection is related to the development of a compensatory reaction aimed at maintaining the needed level of the blood supply to the organs and tissues--i. e. at "systemic autoregulation".