Related Experiment Video
Updated: Jul 21, 2026
Isolation and Time-Lapse Imaging of Primary Mouse Embryonic Palatal Mesenchyme Cells to Analyze Collective Movement Attributes
Published on: February 13, 2021
[A comparative morphometrical study on development of anterior septonasal accessory organs in the cleft palate mice]
Z Cai1, H von Domarus, E Engel
1Department Oral and Maxillofacial Surgery, Peking University School of Stomatology.
Objective:
The aim of this study was to investigate whether cleft palate is associated with the mal-development of the vomer, Jacobson's organ and para-septal cartilage.
Methods:
Sixty craniomaxillary complexes, which came from 30 pairs of trisomy 18 with cleft palate (Ts + CP) and euploid mouse fetuses were precisely orientated in the coronal plane, and serially sectioned at 7 microns thickness. With the aid of computer imaging analysis system the vomer in coronal and sagittal direction, Jacobson's organ and para-septal cartilage in the boundary plane of the primary and secondary palate were measured and compared quantitatively.
Results:
The hard tissues (including the vomer and para-septal cartilage) of the anterior nasal septum in Ts + CP foetuses show serious developmental hypoplasia, however, the Jacobson's organ had no significant different between the cleft and non-cleft samples.
Conclusion:
Development hypoplasia of these hard tissues may be more closely related with the autosomal trisomic condition more than the cleft palate.
