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[A study of millimeter wave's clinical and immunological effects on oral lichen planus patients]
Objective:
The aim of this study is to observe clinical effects of the millimeter wave on oral lichen planus (OLP) and its immune mechanisms.
Methods:
30 patients with OLP were randomized into the millimeter wave group and the control group. 15 patients in the millimeter wave group were treated with millimeter wave (7.1 mm, 43 GHz, 10 mW/cm2) radiation, while the other 15 patients in the control group were just given soothing treatment. Either before or after the therapy procedure, the clinical manifestations and the T-cell sub-grouping in the peripheral circulation of each patient were double-blindly evaluated.
Results:
The pain-soothing effect in the patients treated with millimeter wave was much more obvious than that of the control group (P < 0.01). The peripheral blood CD8+ percent of millimeter wave group decreased greatly (P < 0.05), while no obvious CD8+ change was observed in the control group (P > 0.05). The millimeter wave group's CD4+/CD8+ improvement was also much more obvious than that of the control group (P < 0.05), and its CD4+/CD8+ ratio was completely recovered to the normal level.
Conclusion:
Millimeter wave can effectively relieve OLP patients' pain, and can regulate OLP patients' cellular immune condition. Millimeter wave might provide a new treatment method for OLP.
Insights
Millimeter wave therapy significantly reduced pain and improved immune cell balance in oral lichen planus (OLP) patients. This novel treatment shows promise for OLP management.
Area of Science:
- Immunology
- Dermatology
- Biophysics
Background:
- Oral lichen planus (OLP) is a chronic inflammatory condition affecting oral mucosa.
- Current treatments for OLP have limitations in efficacy and side effects.
- Understanding OLP's immune mechanisms is crucial for developing new therapies.
Purpose of the Study:
- To evaluate the clinical efficacy of millimeter wave therapy on OLP.
- To investigate the impact of millimeter wave therapy on immune mechanisms in OLP patients.
Main Methods:
- A randomized controlled trial involving 30 OLP patients.
- Patients were assigned to either millimeter wave treatment or a control group receiving soothing care.
- Clinical symptoms and peripheral blood T-cell subsets were assessed using double-blind evaluations.
Main Results:
- Millimeter wave therapy demonstrated a significant pain-soothing effect compared to the control group (P < 0.01).
- A notable decrease in peripheral blood CD8+ T-cells was observed in the millimeter wave group (P < 0.05).
- The CD4+/CD8+ ratio significantly improved in the millimeter wave group, normalizing to levels seen in healthy individuals (P < 0.05).
Conclusions:
- Millimeter wave therapy is effective in alleviating pain associated with OLP.
- This therapy modulates the cellular immune response in OLP patients.
- Millimeter wave therapy presents a potential new treatment modality for oral lichen planus.
