Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human prion diseases.

Rajeev Thakur1, Yasmeen Marbaniang Vincent, Sujata Chaturvedi

  • 1Department of Microbiology, Institute of Human Behaviour and Allied Sciences, PO Box 9520, Jhimill, Dilshad Garden, Delhi 110095, India. drrajeevthakur@hotmail.com

The National Medical Journal of India
|January 24, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Analysis of Histomorphologic/Molecular Association and Immune Checkpoint Regulators in Epithelioid Glioblastoma and Pleomorphic Xanthoastrocytoma: Are These Tumors Potential Candidates for Immune Checkpoint Blockade?

Applied immunohistochemistry & molecular morphology : AIMM·2023
Same author

Primary Dural Non-Hodgkin's Lymphoma as a Diagnostic Pitfall: Report of a Rare Presentation with Review of Literature.

Journal of microscopy and ultrastructure·2023
Same author

Multiple Primary Bilateral Cerebral <i>Echinococcosis</i> in an Adult: A Neurological Rarity.

Asian journal of neurosurgery·2022
Same author

Extra-axial adult cerebellopontine angle medulloblastoma: Revisiting a rare entity.

Journal of cancer research and therapeutics·2022
Same author

Skull Base Chordoma Extending into the Oropharynx and Upper Cervical Spine: A Diagnostic Dilemma.

Neurology India·2022
Same author

Gene expression based profiling of pleomorphic xanthoastrocytoma highlights two prognostic subgroups.

American journal of translational research·2022
Same journal

Robotic surgery: The beginning and the journey so far.

The National medical journal of India·2026
Same journal

Workplace violence against junior doctors in a tertiary care hospital in Manipur and coping strategies: A mixed-method study.

The National medical journal of India·2026
Same journal

Digital library of court cases of the main hospital of the All India Institute of Medical Sciences, New Delhi: An innovation to deal with hospital litigations.

The National medical journal of India·2026
Same journal

Benidipine-induced lichenoid drug eruption.

The National medical journal of India·2026
Same journal

Aortoplasty balloon catheter for aortic occlusion in patients with massive truncal haemorrhage: A cadaveric study.

The National medical journal of India·2026
Same journal

Cutaneous tuberculosis: Prevention, management, challenges and future perspectives.

The National medical journal of India·2026
See all related articles

Prion diseases, or transmissible spongiform encephalopathies, are rare neurodegenerative disorders. Diagnosis relies on brain tissue examination and specific tests, but effective treatments and sterilization methods remain challenging due to the unique nature of prions.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Molecular Biology

Background:

  • Prion diseases, also known as transmissible spongiform encephalopathies (TSEs), encompass a group of fatal neurodegenerative disorders.
  • Creutzfeldt-Jakob disease (CJD) is the most common human prion disease, presenting in sporadic, familial, or iatrogenic forms.
  • Specific mutations in the prion protein gene are linked to familial forms like familial CJD, Gerstmann-Sträussler-Scheinker disease, and fatal familial insomnia.

Purpose of the Study:

  • To review the characteristics of human prion diseases, including their classification and etiology.
  • To discuss diagnostic methods for prion diseases, emphasizing the limitations of antemortem diagnosis.
  • To highlight the challenges posed by prion agents in terms of treatment, surveillance, and control.

Main Methods:

Related Experiment Videos

  • Review of existing literature on prion diseases and transmissible spongiform encephalopathies.
  • Analysis of diagnostic approaches, including neuropathological examination and laboratory tests.
  • Discussion of the unique properties of prion agents and their implications.

Main Results:

  • Human prion diseases include sporadic, familial, and iatrogenic CJD, as well as variant CJD (vCJD) potentially linked to bovine spongiform encephalopathy.
  • Antemortem diagnosis is challenging, with brain tissue examination being definitive, while immunological tests (ELISA, Western blot) and 14-3-3 protein assays in cerebrospinal fluid are key diagnostic tools.
  • Conventional disinfection and sterilization methods are ineffective against prion agents, posing significant challenges for disease control.

Conclusions:

  • Prion diseases represent a unique class of disorders with distinct diagnostic and therapeutic challenges.
  • The emergence of variant CJD underscores the zoonotic potential of prion diseases and the need for effective surveillance.
  • Further research into prion biology is crucial for developing effective treatments and control strategies for these devastating diseases.