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Updated: Sep 27, 2026

Structure-Guided Design and Development of Novel Cyclophilin A Inhibitors and Ganoderiol-F Derivatives: An In-Silico Approach
Published on: June 23, 2026
Hybrid-designed inhibitors of p38 MAP kinase utilizing N-arylpyridazinones
Steven L Colletti1, Jessica L Frie, Elizabeth C Dixon
1Merck Research Laboratories, Merck & Co., Inc., Rahway, New Jersey 07065, USA. steve_colletti@merck.com
Abstract:
Imidazo[1,2-a]pyridyl N-arylpyridazinones were hybridized from the classic pyridinylimidazoles and the more recent dual hydrogen bond acceptors, resulting in a new structural class of selective p38 MAP kinase inhibitors.
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