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Updated: Sep 27, 2026

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
Published on: December 18, 2016
Rapid MR imaging of articular cartilage with steady-state free precession and multipoint fat-water separation
Scott B Reeder1, Norbert J Pelc, Marcus T Alley
1Department of Radiology, Stanford University Medical Center, 300 Pasteur Ave., Rm. H1306, Stanford, CA 94304, USA.
Objective:
To obtain high-quality high-resolution images of articular cartilage with reduced imaging time, we combined a novel technique of generalized multipoint fat-water separation with three-dimensional (3D) steady-state free precession (SSFP) imaging.
Subjects And Methods:
The cartilage of 10 knees in five healthy volunteers was imaged with 3D SSFP imaging and a multipoint fat-water separation method capable of separating fat and water with short TE increments. Fat-saturated 3D spoiled gradient-echo (SPGR) images were obtained for comparison.
Results:
High-quality images of the knee with excellent fat-water separation were obtained with 3D SSFP imaging. Total imaging time required was 58% less than that required for 3D SPGR imaging with a comparable cartilage signal-to-noise ratio and spatial resolution. Unlike 3D SPGR images, 3D SSFP images exhibited bright synovial fluid, providing a potential arthrographic effect.
Conclusion:
High-quality high-resolution images of articular cartilage with improved fat-water separation, bright synovial fluid, and markedly reduced acquisition times can be obtained with 3D SSFP imaging combined with a fat-water separation technique.
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