[Determination of bifonazole in cream by high performance liquid chromatography]

An accurate method for the determination of bifonazole in cream is described. The analytical column was packed with Hypersil ODS. The mobile phase was a mixture of 0.08 mol/L aqueous triethylamine (TEA) phosphate solution(pH 7.0)-acetonitrile-methanol (20:10:70, V/V) and the detection wavelength was 254 nm. This method is simple, accurate and can be used for the quality control of bifonazole in cream.