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Hyperhomocysteinaemia and coronary artery disease in the Turkish population

Emine Sipahi1, Gülveren Taskin, Deniz Kumbasar

  • 1Duzen Laboratories Group, Ankara, Turkey. eminesipahi@hotmail.com

Acta Cardiologica
|January 25, 2003
PubMed

Insights

Elevated plasma homocysteine (Hcy) levels are significantly associated with coronary artery disease in Turkish patients. Public health efforts targeting Hcy may help reduce cardiovascular disease prevalence.

Area of Science:

  • Cardiovascular Medicine
  • Clinical Chemistry

Background:

  • Elevated plasma total homocysteine (Hcy) is linked to vascular disease.
  • Understanding this association in specific populations is crucial for public health.

Purpose of the Study:

  • To investigate the relationship between plasma homocysteine levels and coronary artery disease (CAD) in Turkish patients.

Main Methods:

  • Plasma homocysteine levels were measured using HPLC in Turkish patients diagnosed with CAD and age/sex-matched controls.
  • Coronary artery lesions were quantified by angiography, with >70% stenosis defining significant disease.

Main Results:

  • Patients with CAD exhibited significantly higher mean homocysteine concentrations (12.5 µmol/l) compared to controls (8.6 µmol/l).
  • A higher proportion of patients (59%) had homocysteine levels above 11.3 µmol/l compared to controls (21%), indicating a strong association (OR 4.35).

Conclusions:

  • High plasma homocysteine levels are significantly associated with coronary artery disease in the Turkish population.
  • Targeting homocysteine through public health initiatives could potentially lower the burden of cardiovascular disease in Turkey.
Abstract

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