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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
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New bis-secolabdane diterpenoids from Excoecaria agallocha
Tenji Konishi1, Kiyonori Yamazoe, Takao Konoshima
1Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan. konish@mb.kyoto-phu.ac.jp
Journal of Natural Products
|January 25, 2003
Summary
Two novel compounds, excoecarins R1 and R2, were identified from Excoecaria agallocha wood. Their chemical structures were determined using spectroscopic analysis and chemical data.
Area of Science:
- Natural Product Chemistry
- Organic Chemistry
- Phytochemistry
Background:
- Excoecaria agallocha is a plant known for its diverse chemical constituents.
- Diterpenoids are a class of natural products with a wide range of biological activities.
Purpose of the Study:
- To isolate and characterize new chemical compounds from Excoecaria agallocha.
- To elucidate the structures of novel bis-secolabdane diterpenoids.
Main Methods:
- Extraction of resinous wood from Excoecaria agallocha.
- Isolation of compounds using chromatographic techniques.
- Structure elucidation via spectroscopic methods (NMR, MS) and chemical reactions.
Main Results:
- Two new bis-secolabdane diterpenoids, named excoecarins R1 (1) and R2 (2), were successfully isolated.
- The structures of compounds 1 and 2 were fully determined based on comprehensive spectroscopic data and chemical evidence.
Conclusions:
- The study expands the knowledge of diterpenoids found in Excoecaria agallocha.
- The identified compounds, excoecarins R1 and R2, represent new additions to the bis-secolabdane class.
