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Published on: March 8, 2012
A new P-glycoprotein inhibitor from the caper spurge (Euphorbia lathyris)
Giovanni Appendino1, Carla Della Porta, Gwenaëlle Conseil
1Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Viale Ferrucci 33, 28100 Novara, Italy. appendino@pharm.unipmn.it
Abstract:
The macrocyclic lathyrane polyester Euphorbia factor L10 (1a) has been obtained from the seeds of the caper spurge (E. lathyris). The interaction of L10 (1a) and its acetyl derivative (1b) with P-glycoprotein, a multidrug transporter overexpressed in cancer cells and responsible for resistance to chemotherapy, was investigated. The results established lathyrane diterpenoids as a novel chemotype for P-glycoprotein inhibitors.

