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Isolation and structure of the cytotoxic cycloheptapeptide phakellistatin 13
Wen-Lin Li1, Yang-Hua Yi, Hou-Ming Wu
1Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Gou-He Road, Shanghai 200433, People's Republic of China.
Journal of Natural Products
|January 25, 2003
Abstract:
A new cyclic heptapeptide phakellistatin 13 (1) had been isolated from the sponge Phakellia fusca Thiele, collected at Yongxing Island of China. Its structure was elucidated as cyclo-(Pro1-Trp-Leu-Thr-Pro2-Gly-Phe) on the basis of MS, UV, IR, and high-field NMR (600 MHz) analysis. The compound was significantly cytotoxic against the human hepatoma BEL-7404 cell line with an ED(50) < 10(-2) microg/mL.