Related Experiment Video
Updated: Sep 27, 2026

Applications of Liquid-Chromatography Tandem Mass Spectrometry in Natural Products Research: Tropane Alkaloids as a Case Study
Published on: March 8, 2024
New alkaloids from Cephalotaxus fortunei
Mamadou Bocar1, Akino Jossang, Bernard Bodo
1Laboratoire de Chimie des Substances Naturelles, ESA 8041, CNRS, Muséum National d'Histoire Naturelle, 63 Rue Buffon 75005 Paris, France.
Abstract:
Four new cephalotaxus alkaloids, cephalotaxine alpha-N-oxide (1), cephalotaxine beta-N-oxide (2), 11-beta-hydroxycephalotaxine beta-N-oxide (3), and isocephalotaxine (4), were isolated, together with several known alkaloids from an EtOAc extract of the fruits of Cephalotaxus fortunei. The structures were determined by spectral analysis including mass spectrometry and 2D NMR. Compounds 1, 2, 3, and 4 displayed cytotoxicity against nasopharynx KB cells with IC50 values of 30, 14, 31, and 15 micro g/mL, respectively.
Related Concept Videos
Drugs that Stabilize Microtubules
Direct-Acting Cholinergic Agonists: Therapeutic Uses
Direct-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship
The direct-acting...
Drugs that Destabilize Microtubules
Direct-Acting Cholinergic Agonists: Pharmacokinetics
Antifungal Agents
