Related Experiment Videos
Platelet-derived growth factor signaling and human cancer
Jiuhong Yu1, Carolyn Ustach, Hyeong-Reh Choi Kim
1Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University, School of Medicine, Detroit, MI 48201, USA.
Abstract:
Platelet-derived growth factor (PDGF) is a critical regulator of mesenchymal cell migration and proliferation. The vital functions of PDGFs for angiogenesis, as well as development of kidney, brain, cardiovascular system and pulmonary alveoli during embryogenesis, have been well demonstrated by gene knock-out approaches. Clinical studies reveal that aberrant expression of PDGF and its receptor is often associated with a variety of disorders including atherosclerosis, fibroproliferative diseases of lungs, kidneys and joints, and neoplasia. PDGF contributes to cancer development and progression by both autocrine and paracrine signaling mechanisms. In this review article, important features of the PDGF isoforms and their cell surface receptor subunits are discussed, with regards to signal transduction, PDGF-isoform specific cellular responses, and involvement in angiogensis, and tumorstromal interactions.
Insights
Platelet-derived growth factor (PDGF) regulates cell growth and is vital for embryonic development. Aberrant PDGF signaling is linked to diseases like cancer and atherosclerosis.
Area of Science:
- Molecular Biology
- Cell Biology
- Developmental Biology
Background:
- Platelet-derived growth factor (PDGF) is a key regulator of mesenchymal cell migration and proliferation.
- PDGF signaling is essential for embryonic development, including angiogenesis and organogenesis.
- Dysregulated PDGF and its receptor expression are implicated in various diseases, including cancer and fibroproliferative disorders.
Purpose of the Study:
- To review the critical features of PDGF isoforms and their receptor subunits.
- To discuss PDGF's role in signal transduction and isoform-specific cellular responses.
- To explore PDGF's involvement in angiogenesis and tumor-stromal interactions.
Main Methods:
- Literature review of existing studies on PDGF.
- Analysis of gene knock-out approaches demonstrating PDGF functions.
- Examination of clinical studies linking PDGF to disease.
Main Results:
- PDGF isoforms and receptor subunits exhibit diverse signaling pathways.
- PDGF plays a significant role in angiogenesis and embryonic development.
- Aberrant PDGF signaling contributes to cancer development via autocrine and paracrine mechanisms.
Conclusions:
- Understanding PDGF signaling is crucial for comprehending normal development and disease pathogenesis.
- Targeting PDGF pathways holds therapeutic potential for various disorders, including cancer.