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Related Experiment Videos

Calorie restriction in rhesus monkeys.

Julie A Mattison1, Mark A Lane, George S Roth

  • 1Intramural Research Program, Gerontology Research Center, National Institute on Aging, NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA. mattisonj@mail.nih.gov

Experimental Gerontology
|January 25, 2003
PubMed
Summary

Calorie restriction in rhesus macaques shows health benefits, mirroring rodent studies. This nutritional intervention may delay age-related diseases and improve longevity in primates.

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Area of Science:

  • Gerontology
  • Nutritional Science
  • Primate Research

Background:

  • Calorie restriction (CR) is known to extend lifespan and delay age-related diseases in animal models.
  • The National Institute on Aging (NIA) initiated a long-term study in 1987 to investigate CR's effects in rhesus macaques.

Purpose of the Study:

  • To determine if a 30% CR intervention in rhesus macaques yields similar health and longevity benefits observed in rodent studies.
  • To assess the physiological and potential lifespan-extending effects of CR in a long-lived primate species.

Main Methods:

  • A 30% CR was implemented in male and female rhesus macaques of various ages.
  • Physiological parameters including body weight, fat mass, glucoregulation, blood pressure, blood lipids, and body temperature were monitored.

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  • Skeletal maturation, sexual maturation, bone mass, reproductive hormones, and menstrual cycling were assessed in relevant age groups.

    • Main Results:

    • CR led to decreased body weight, fat mass, blood pressure, blood lipids, and body temperature.
    • Improved glucoregulatory function was observed.
    • Juvenile males showed delayed skeletal and sexual maturation; adult female bone mass, reproductive hormones, and menstrual cycles were unaffected.
    • CR attenuated age-associated declines in dehydroepiandrosterone (DHEA) and melatonin in males.
    • Preliminary data indicates 81% survival rate, suggesting CR's beneficial impact on morbidity and mortality.

    Conclusions:

    • Calorie restriction in rhesus macaques induces physiological changes that parallel findings in rodent models.
    • CR demonstrates potential for delaying age-related disease onset and maintaining function in primates.
    • Ongoing analysis aims to provide a comprehensive understanding of CR's effectiveness in promoting healthy aging and longevity.