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Updated: Sep 27, 2026

Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers
Published on: August 18, 2017
Preparative chiral chromatographic resolution of enantiomers in drug discovery
Shalini Andersson1, Stig G Allenmark
1AstraZeneca R&D Mölndal, SE-43183 Mölndal, Sweden. shalini.andersson@astrazeneca.com
Abstract:
A brief account is given of the role of preparative chromatography for the direct separation of enantiomers in the drug discovery process. Although it is not yet possible to predict the outcome of a chromatographic resolution attempt, and the optimisation procedure sometimes might be time-consuming, the technique is still indispensable as a means to obtain both enantiomers in pure form from a drug racemate for biological testing. The most suitable types of chiral stationary phases (CSPs) available for this purpose are discussed with special reference to loadability and compatibility with different mobile phase systems.
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