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Related Experiment Videos

Polymicrobial candidemia.

Suzanne Pulimood1, Latha Ganesan, George Alangaden

  • 1Division of Infectious Diseases, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan, USA.

Diagnostic Microbiology and Infectious Disease
|January 25, 2003
PubMed
Summary

Polymicrobial candidemia, a rare fungal infection, affects sicker patients with co-morbidities and bacterial infections. Treatment involves removing catheters and antifungal therapy.

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Area of Science:

  • Infectious Diseases
  • Mycology
  • Clinical Medicine

Background:

  • Polymicrobial candidemia is infrequently documented.
  • Candida species are a significant cause of hospital-acquired infections.

Purpose of the Study:

  • To review clinical data of patients with polymicrobial candidemia.
  • To compare clinical features of polymicrobial versus monomicrobial candidemia.

Main Methods:

  • Retrospective review of clinical data from 1992-2000.
  • Analysis of 303 patients with candidemia, identifying 16 with polymicrobial infections.
  • Comparison of patient demographics, co-morbidities, and outcomes.

Main Results:

  • Polymicrobial candidemia occurred in 5.2% of patients.

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  • Patients were older, had co-morbidities, prolonged hospitalization, and frequent bacterial infections.
  • Candida albicans was the most common species; catheter-tip cultures frequently yielded causative species.
  • Mortality was 43%, similar to monomicrobial candidemia.
  • Conclusions:

    • Polymicrobial candidemia is uncommon, affecting severely ill patients with extensive colonization.
    • Key therapeutic interventions include vascular catheter removal and antifungal treatment.