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Comparison of methods of interpretation of checkerboard synergy testing
Charles R Bonapace1, John A Bosso, Lawrence V Friedrich
1Anti-Infective Research Laboratory, College of Pharmacy, Medical University of South Carolina, Charleston, SC, USA.
Diagnostic Microbiology and Infectious Disease
|January 25, 2003
Abstract:
Four different methods for interpreting the results of checkerboard synergy testing were compared by applying each to a set of synergy study data. Statistically significant differences in synergy were detected among methods (% synergy ranged from 10 to 83%). As interpretations were found to vary widely based upon method, one should be aware of this in interpreting the relevant literature.