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Related Experiment Videos

Equine platelet CD62P (P-selectin) expression: a phenotypic and morphologic study.

Cory C Lalko1, Elisabeth Deppe, Dan Ulatowski

  • 1Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706-1102, USA.

Veterinary Immunology and Immunopathology
|January 25, 2003
PubMed
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Equine platelets show high baseline P-selectin expression, unlike humans, suggesting they are primed for leukocyte adhesion. This may contribute to prothrombotic conditions in horses with inflammatory diseases like colic.

Area of Science:

  • Veterinary Immunology
  • Equine Hematology
  • Thrombosis Research

Background:

  • Acute inflammatory diseases in horses (colic, septicemia, endotoxemia) are linked to vascular injury and thrombosis.
  • In humans, P-selectin and PSGL-1 mediate platelet-leukocyte adhesion, contributing to thrombotic disorders.

Purpose of the Study:

  • To investigate equine platelet activation, focusing on P-selectin (CD62P) expression.
  • To examine P-selectin-mediated platelet-leukocyte interactions in horses.

Main Methods:

  • Used thrombin to induce platelet activation and aggregation in equine and human platelets.
  • Blocked fibrin polymerization with GPRP to enable flow cytometry analysis of P-selectin expression.
  • Measured alpha-granule release as an indicator of platelet activation.

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Main Results:

  • Thrombin activation significantly increased P-selectin expression in both human and equine platelets.
  • Healthy horses exhibit high constitutive P-selectin expression (20-25%) on resting platelets, unlike humans (<5%).
  • This high baseline suggests equine platelets may be primed for leukocyte adhesion.

Conclusions:

  • Equine platelets have a higher baseline P-selectin expression than human platelets.
  • This may predispose horses to prothrombotic states, relevant to inflammatory diseases.
  • Further research into P-selectin-mediated inflammation and vascular injury in horses is warranted.