[Concentration course of Na-Penicillin G in wound secretions following vascular surgery]

After infusion of 10 and 20 M.I.U. of Na-penicilline G, the concentrations in serum, wound exudation, and urine were analysed, at equal points of time, following vascular reconstruction; pharmacokinetic data were calculated as well. The importance of local concentration of antibiotics for therapy and prevention of infections is emphasized - according to pharmacokinetics - in relation to the blood level. Simultaneously, the influence of pathological changes is discussed and represented by a brief case follow-up.