Related Experiment Videos
Oxidative stress in juvenile essential hypertension
Sàndor Túri1, Aaron Friedman, Csaba Bereczki
1Department of Pediatrics, Albert Szent-Györgyi Medical and Pharmaceutical Center, University of Szeged, Korànyi fasor 14-15, Szeged H-6721, Hungary. turisand@pedia.szote.u-szeged.hu
Journal of Hypertension
|January 25, 2003
Summary
Juvenile essential hypertension is linked to systemic oxidative stress, evidenced by altered nitric oxide and lipid peroxidation markers. This imbalance in antioxidant/pro-oxidant status occurs regardless of body mass index in hypertensive children and adolescents.
Area of Science:
- Biochemistry
- Pediatric Cardiology
- Oxidative Stress Research
Background:
- Juvenile essential hypertension is a growing concern, with its association with body mass index (BMI) being a key factor.
- Understanding the underlying pathophysiological mechanisms, including oxidative stress, is crucial for effective management.
Purpose of the Study:
- To investigate systemic oxidative stress in children and adolescents with essential hypertension.
- To compare biochemical markers of oxidative stress between hypertensive patients and BMI-matched controls.
Main Methods:
- A prospective observational study involving 52 hypertensive children/adolescents and 48 BMI-matched controls.
- Measurement of plasma nitrites/nitrates (nitric oxide indicator), lipid peroxidation end-products, and red blood cell glutathione redox status.
Main Results:
- Hypertensive patients exhibited decreased plasma nitrates and increased lipid peroxidation end-products, leading to a higher lipid peroxidation/nitric oxide ratio (P <0.01).
- This ratio correlated directly with systolic and diastolic blood pressures (P <0.001).
- Red blood cell glutathione depletion indicated reduced antioxidant capacity in hypertensive individuals (P <0.001).
Conclusions:
- Systemic oxidative stress is present in hypertensive children and adolescents.
- This oxidative stress is independent of body mass index in this population.