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Human albumin synthesis is increased by an ultra-endurance trial
Isabelle Mischler1, Yves Boirie, Pierre Gachon
1Laboratoire de Physiologie-Biologie du Sport, Faculté de Médecine, Université d'Auvergne, Clermont-Ferrand, France.
Purpose:
The purpose of this study was to determine whether an ultra-endurance event is a strong stimulus to increase albumin synthesis involved in the process of intravascular albumin mass increase associated with transient hypervolemia.
Methods:
The albumin synthetic rate was measured in six young men, 3 d before (C) and on the 1st (R1) and 8th (R8) days of the recovery from an ultra-endurance trial (5 h daily for 4 d). Albumin fractional (FSR) and absolute (ASR) synthetic rate were determined using a primed-constant infusion of [1(-13) C] leucine. Plasma volume (PV) using Evans Blue dye dilution and total body water (TBW) using bioelectrical impedance analysis were measured on C, R1, and R8.
Results:
On R1 as compared with C: 1). PV (+23.3 +/- 3.2%; P
Conclusion:
The increase in the albumin synthetic rate the day after an ultra-endurance trial is a major event associated with a greater circulating protein mass. The impact of exercise on albumin synthesis has disappeared 8 d later, as did PV and total protein mass expansion.