Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Protein phosphatase 2A: its structure, function and activity regulation].

Wei-Jun Liu1, Ying Shen, Jian Ding

  • 1Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, the Chinese Academy of Sciences, Shanghai 200031, China.

Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica Et Biophysica Sinica
|January 25, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Discovery of novel 2,4-diarylaminopyrimidine derivatives as potent and selective epidermal growth factor receptor (EGFR) inhibitors against L858R/T790M resistance mutation.

European journal of medicinal chemistry·2018
Same author

Discovery of 4,7-Diamino-5-(4-phenoxyphenyl)-6-methylene-pyrimido[5,4- b]pyrrolizines as Novel Bruton's Tyrosine Kinase Inhibitors.

Journal of medicinal chemistry·2018
Same author

Both saccadic and manual responses in the amblyopic eye of strabismics are irreducibly delayed.

Journal of vision·2018
Same author

Oncogene-induced senescence: a double edged sword in cancer.

Acta pharmacologica Sinica·2018
Same author

Decreased interhemispheric homotopic connectivity in Parkinson's disease patients with freezing of gait: A resting state fMRI study.

Parkinsonism & related disorders·2018
Same author

Structure-Based Discovery of a Series of 5H-Pyrrolo[2,3-b]pyrazine FGFR Kinase Inhibitors.

Molecules (Basel, Switzerland)·2018

Protein phosphatase 2A (PP2A) is a crucial enzyme regulating cell processes and linked to diseases like cancer. Its activity is controlled by various factors, including ceramide signaling.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Context:

  • Protein phosphatase 2A (PP2A) is a key serine/threonine phosphatase in eukaryotic cells.
  • PP2A exists as diverse holoenzymes formed by various subunits and isozymes.
  • PP2A is implicated in fundamental cellular processes and diseases.

Purpose:

  • To highlight the multifaceted roles of PP2A in cellular functions.
  • To underscore the significance of PP2A in human health and disease.
  • To outline the regulatory mechanisms governing PP2A activity.

Summary:

  • PP2A regulates critical cellular activities including cell cycle, signal transduction, differentiation, and transformation.
  • Dysregulation of PP2A is associated with neurodegenerative diseases and cancer.

Related Experiment Videos

  • PP2A activity is modulated by subunit expression, localization, post-translational modifications (phosphorylation, methylation), ceramide, and small molecule inhibitors.

    • Impact:

    • Understanding PP2A regulation is vital for developing therapeutic strategies for cancer and neurodegenerative disorders.
    • Elucidating PP2A's role provides insights into fundamental cell biology.
    • Identification of PP2A inhibitors offers potential for targeted drug development.