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Sectorial keratitis and uveitis: differential diagnosis.

Stefanos Baltatzis1, Tatiana Romero-Rangel, C Stephen Foster

  • 1Ocular Immunology and Uveitis Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA.

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
|January 25, 2003
PubMed
Summary

Herpes simplex virus is a key cause of sectorial keratitis and uveitis, often requiring prompt diagnosis and treatment to prevent vision loss. Early intervention with steroids and antivirals is crucial for managing this condition.

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Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Immunology

Background:

  • Sectorial keratitis and uveitis present a diagnostic challenge in ophthalmology.
  • Understanding the differential diagnosis is crucial for effective patient management.

Observation:

  • A review of six patients revealed herpes simplex viral stromal keratitis as the primary diagnosis.
  • Patients presented with posterior corneal infiltrates, anterior non-granulomatous uveitis, and often glaucoma and corneal scarring.

Findings:

  • Herpes simplex virus was identified as the cause in all reviewed cases of sectorial keratitis and uveitis.
  • Most patients responded to topical steroids and antiviral therapy, but one required immunomodulation.
  • Complications included glaucoma and corneal scarring, highlighting the severity of the condition.

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Implications:

  • Ophthalmologists must consider herpes simplex virus in the differential diagnosis of sectorial keratitis and uveitis.
  • Prompt and accurate diagnosis is essential for appropriate management and preventing sight-threatening complications.
  • Familiarity with diverse, potentially vision-threatening entities is vital for ophthalmologists.