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A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate
Published on: May 3, 2021
[Therapy of osteoid osteomas -- always surgically?]
S Winkelmann1, W Hirsch, S Burdach
1Abteilung für Kinderheilkunde, Kreiskrankenhaus Torgau, Torgau.
Klinische Padiatrie
|January 25, 2003
Summary
Osteoidosteomas, benign bone tumors, often cause night pain relieved by NSAIDs. Conservative treatment with NSAIDs and physiotherapy can be effective, avoiding surgical risks.
Area of Science:
- Orthopedics
- Pediatric Oncology
- Radiology
Background:
- Osteoidosteomas are common, benign bone tumors typically affecting children and adolescents.
- They most frequently occur in long bones, presenting with nocturnal pain relieved by nonsteroidal anti-inflammatory drugs (NSAIDs).
Observation:
- This study presents two pediatric cases of osteoidosteoma in the proximal femur.
- One patient experienced complications after surgical excision, while the other's pain resolved with conservative management.
Findings:
- Both patients achieved complete pain control with NSAIDs; associated hip contractions resolved with physiotherapy.
- Serial MRI demonstrated significant regression of inflammation and tumor disappearance in one case.
Implications:
- Pharmacomedical therapy, including NSAIDs, is a viable treatment option for osteoidosteomas when diagnosed definitively and monitored closely.
- This approach should be weighed against the risks associated with anesthesia and surgical interventions.

