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Published on: August 13, 2019
[Effect of 5 polycyclic aromatic hydrocarbons on estrogen receptor binding in rats]
1Department of Toxicology, Second Military Medical University, Shanghai 200433, China.
Abstract:
The estrogenic activity of 5 polycyclic aromatic hydrocarbons(PAHs) of rat uterine wet weight bioassy and estrogen receptor binding bioassy are determined. The results show that penzo(a)pyrene, 7,12-dimethyl benz(a)anthracene and pentacene could statistically increase uterine wet weight of immature female rats(P < 0.01 or P < 0.05) while benz(a)anthracene and chrysene can not significantly increase uterine wet weight(P > 0.05). Penzo(a)pyrene, 7,12-dimethyl benz(a)anthracene and pentacene effectively inhibit the specific 3H-estradial binding to rat uterine estrogen receptor(P < 0.01). Whereas benz(a)anthracene and chrysene can not inhibit the specific 3H-estradial binding to rat uterine estrogen receptor(P > 0.05). The results from this study indicate that penzo(a)pyrene, 7,12-dimethyl benz(a) anthracene and pentacene have significant estrogenic activity.
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