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Related Experiment Videos

Autonomic nerve dysfunction in pathologically obese patients.

E Surrenti1, G Ciancio, S Carloppi

  • 1Gastroenterology Unit, Department of Clinical Physiopathology, University of Florence, Azienda Ospedaliera Careggi, Florence, Italy. E.Surrenti@dfc.unifi.it

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
|January 28, 2003
PubMed
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Pathologically obese patients exhibit reduced esophageal transit and autonomic nervous system dysfunction. However, this study found no direct correlation between these gastrointestinal motility and nervous system changes.

Area of Science:

  • Gastroenterology
  • Cardiology
  • Obesity Medicine

Background:

  • Obesity is frequently associated with gastrointestinal motility issues and autonomic nervous system (ANS) dysfunction.
  • Understanding these connections is crucial for managing obese patients.

Purpose of the Study:

  • To investigate the potential relationship between cardiovascular autonomic nervous dysfunction and esophageal motility in individuals with pathological obesity.

Main Methods:

  • 22 pathologically obese patients and 10 healthy controls were assessed.
  • Esophageal motility was evaluated using stationary manometry and scintigraphic transit.
  • Autonomic nervous system function was tested via Valsalva ratio, deep breathing, handgrip, sudormotor axon reflex test, and R-R interval spectral analysis.

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Main Results:

  • Obese patients showed significantly slower esophageal transit times (22.96s vs 10.23s) and reduced peristaltic wave pressure (39.36 mmHg vs 73 mmHg) compared to controls.
  • Spectral analysis indicated increased parasympathetic activity in obese patients.
  • Other ANS tests did not reveal significant differences between groups.

Conclusions:

  • Obese patients demonstrate impaired esophageal transit and ANS dysfunction.
  • No direct correlation was identified between these specific esophageal motility and autonomic nervous system alterations in this study.