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Structure and mechanism of the oestrogen receptor
E H Kong1, A C W Pike, R E Hubbard
1Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York YO10 5YW, UK.
Biochemical Society Transactions
|January 28, 2003
Abstract:
We have determined the structures of the oestrogen receptor ligand-binding domain in complex with a range of ligands and with fragments of co-regulator proteins. These structures provide insights into the structural mechanisms underlying the receptor's complex pharmacological properties and how the conformation of the receptor modulates its ability to recruit co-regulators that are necessary for transcriptional activation.