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Anti-inflammatory and anti-platelet aggregation activity of human placental extract
Tapas Kumar Sur1, Tuhin Kanti Biswas, Liaquat Ali
1Department of Pharmacology, Dr BC Roy Postgraduate Institute of Basic Medical Sciences 244B, Acharya J C Bose Road, Calcutta 700020, India.
Aim:
To find the anti-inflammatory and anti-platelet aggregatory activity of human placental extract (HPE, Placentrex).
Methods:
The HPE was studied for anti-inflammatory effect in Wistar rats on carrageenin, serotonin (5-HT), and prostaglandin E1 (PGE1) induced edema in acute model and cotton pellet induced granuloma on sub-acute model. Anti-platelet aggregation was studied against protection of adinosine diphosphate (ADP)-induced aggregation of human platelet through in vitro study.
Results:
HPE showed positive results both in acute and sub-acute models of inflammation. Highly significant (P<0.01) results were obtained against 5-HT induced acute inflammation and cotton pellet induced sub-acute inflammation in comparison with standard (diclofenac sodium) and control (normal saline) drugs. The anti-inflammatory property of HPE in animal model was well supported with clinical study of platelet aggregation. There was highly significant (P<0.01) inhibition of platelet aggregation with HPE at different doses against ADP.
Conclusion:
Our data suggest that human placental extract may be useful in suppressing inflammation and platelet aggregation.