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Permeability issues in nasal drug delivery.
Priyanka Arora1, Shringi Sharma, Sanjay Garg
1Dept. of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar, Punjab 160062, India.
Drug Discovery Today
|January 28, 2003
Summary
The nasal route offers rapid drug absorption and is ideal for delivering sensitive compounds. Understanding factors affecting nasal permeability is key for effective drug delivery without harming nasal physiology.
Area of Science:
- Pharmacology
- Drug Delivery
- Biotechnology
Background:
- The nasal cavity is highly permeable and vascularized, enabling rapid drug absorption.
- It serves as an alternative route for drugs with poor bioavailability and for delivering large biomolecules.
- Nasal drug delivery is explored for proteins, peptides, steroids, and vaccines.
Purpose of the Study:
- To review factors influencing drug and biomolecule permeability through the nasal mucosa.
- To provide insights for optimizing nasal drug delivery.
- To ensure therapeutic efficacy without adverse effects on nasal physiology.
Main Methods:
- Literature review of factors affecting nasal drug permeability.
- Analysis of biological, formulation, and device-related factors.
- Synthesis of information on optimizing nasal drug delivery.
Main Results:
- Identified key biological factors influencing nasal drug absorption.
- Highlighted the impact of formulation characteristics on nasal permeability.
- Discussed device-related aspects crucial for effective nasal delivery.
- Emphasized the potential for achieving desired plasma concentrations via nasal route.
Conclusions:
- Nasal drug delivery is a viable route for various therapeutic agents, including biologics.
- Optimizing nasal permeability requires careful consideration of biological, formulation, and device factors.
- This knowledge aids in developing safe and effective nasal drug delivery systems.