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Related Experiment Videos

In need of high-throughput behavioral systems.

Dani Brunner1, Eric Nestler, Emer Leahy

  • 1Psychogenics, 4 Skyline Drive, Hawthorne, NY 10532, USA. daniela.brunner@psychogenics.com

Drug Discovery Today
|January 28, 2003
PubMed
Summary

High-throughput systems accelerate drug discovery by improving in vivo behavioral testing in mice. These advanced methods enable faster analysis, aiding in the discovery of novel central nervous system (CNS) drugs and gene function.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Biotechnology

Background:

  • In vivo behavioral testing in mice is crucial for drug discovery and understanding gene function.
  • Current methods are slow, creating a bottleneck in the drug discovery pipeline, especially for central nervous system (CNS) drugs.
  • Predicting human efficacy from mouse models requires accurate and efficient behavioral analysis.

Purpose of the Study:

  • To address the bottleneck in drug discovery by developing higher-throughput systems for behavioral, neurological, and physiological analyses.
  • To integrate these systems with pharmacological databases and bioinformatic algorithms for rapid drug potential assessment.
  • To enhance the efficiency of target validation through rapid characterization of novel mutant mice.

Main Methods:

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  • Development of high-throughput systems for behavioral, neurological, and physiological analyses in mice.
  • Integration of these systems with large pharmacological databases.
  • Application of state-of-the-art bioinformatic and data-mining algorithms.

    • Main Results:

    • Significant increase in the speed and reliability of behavioral testing.
    • Provision of rapid and accurate indices for assessing the therapeutic potential of novel drugs.
    • Facilitation of whole drug-library screening and compound profiling.

    Conclusions:

    • High-throughput systems substantially increase the speed of behavioral research, enabling faster and more reliable approaches.
    • These advancements facilitate the discovery of novel CNS drugs by enabling efficient screening and comparison of compounds.
    • Target validation is improved through the rapid characterization of novel mutant mice, accelerating the drug discovery process.