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Related Experiment Videos

High-throughput cell-based assays in yeast.

Chandra L Tucker1

  • 1Dept of Genome Sciences, University of Washington, Box 357730, Seattle, WA 98195, USA. ctucker@u.washington.edu

Drug Discovery Today
|January 28, 2003
PubMed
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Post-genomic research uses yeast cell-based assays for high-throughput functional genomics and drug discovery. Saccharomyces cerevisiae aids in understanding protein functions and cellular networks in health and disease.

Area of Science:

  • Molecular Biology
  • Genomics
  • Biochemistry

Background:

  • The completion of numerous genome sequencing projects presents a challenge in determining protein functions and interactions.
  • Understanding cellular networks and protein roles is crucial for comprehending cellular function in both healthy and diseased conditions.

Purpose of the Study:

  • This review focuses on the application of yeast cell-based assays in the post-genomic era.
  • The review highlights the utility of these assays for large-scale functional genomics and drug discovery.

Main Methods:

  • Utilizing the budding yeast Saccharomyces cerevisiae as a model organism.
  • Employing yeast cell-based assays for high-throughput screening.

Main Results:

Related Experiment Videos

  • Saccharomyces cerevisiae has become a valuable tool for large-scale functional genomics.
  • Yeast assays facilitate the deciphering of protein functions and interactions within cellular networks.

Conclusions:

  • Yeast cell-based assays are essential for advancing functional genomics in the post-genomic era.
  • These assays are instrumental in accelerating drug discovery and understanding cellular mechanisms.