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Identification of protein complexes with quantitative proteomics in S. cerevisiae
Published on: March 4, 2009
Protein complexes and proteome organization from yeast to man
Anne-Claude Gavin1, Giulio Superti-Furga
1Cellzome AG, Meyerhofstrasse 1 69117 Heidelberg, Germany. anne-claude.gavin@cellzome.com
Current Opinion in Chemical Biology
|January 28, 2003
Summary
Cellular functions rely on protein complexes, which are regulated in time and space. Recent studies reveal their modularity and interactions, mapping the proteome organization.
Area of Science:
- Molecular Biology
- Cell Biology
- Systems Biology
Background:
- Protein complexes are fundamental molecular units driving cellular functions.
- Regulation of protein complex activity in time and space is crucial for cellular programs.
- Cells integrate complex activities like a factory with networked assembly lines.
Purpose of the Study:
- To provide insights into the properties of cellular protein complexes.
- To understand the modular nature and interactions of protein complexes.
- To develop a preliminary organization chart of the proteome.
Main Methods:
- Proteome-wide studies.
- Analysis of protein complex properties.
- Investigation of inter-complex interactions.
Main Results:
- Cellular protein complexes exhibit modular characteristics.
- Interactions between protein complexes are significant for cellular organization.
- A preliminary organizational framework of the proteome has been elucidated.
Conclusions:
- Protein complexes are key regulators of cellular processes.
- Understanding proteome organization through complex interactions is vital.
- This work lays the groundwork for further systems-level analysis of cellular function.
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