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The changing concept of epigenetics.

Eva Jablonka1, Marion J Lamb

  • 1Cohn Institute for the History and Philosophy of Science and Ideas, Tel Aviv University, Tel Aviv 69978, Israel. jablonka@post.tau.ac.il

Annals of the New York Academy of Sciences
|January 28, 2003
PubMed
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Epigenetics studies how cells commit to functions and transmit traits. Modern epigenetics broadens heredity concepts beyond DNA, impacting evolution and challenging neo-Darwinism.

Area of Science:

  • Developmental Biology
  • Genetics
  • Evolutionary Biology

Background:

  • Epigenetics, coined by Conrad Waddington, originally studied gene-phenotype relationships.
  • The modern focus is on cellular commitment and transmission of functional states through cell lineages.

Observation:

  • The epigenetic approach to development differs from the traditional genetic approach.
  • Cells acquire specific forms and functions through epigenetic mechanisms.

Findings:

  • Modern epigenetics investigates mechanisms of cellular commitment and heritability.
  • Non-DNA variations can be transmitted via epigenetic inheritance systems.

Implications:

  • Epigenetics has practical applications in medicine, agriculture, and conservation.

Related Experiment Videos

  • Recognizing epigenetic inheritance broadens the definition of heredity.
  • It challenges the gene-centered neo-Darwinian view of evolution.