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Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)
04:12

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Published on: December 19, 2019

Chemoprevention of skin cancer: current status and future prospects

Sanjay Gupta1, Hasan Mukhtar

  • 1Department of Urology, Case Western Reserve University & The Research Institute of University Hospitals of Cleveland, Cleveland, OH, USA.

Cancer Metastasis Reviews
|January 29, 2003
PubMed

Insights

Chemoprevention agents, both natural and synthetic, show promise in slowing or halting skin cancer. Further research is needed to confirm their efficacy in humans for cancer prevention.

Area of Science:

  • Oncology
  • Dermatology
  • Preventive Medicine

Background:

  • Skin cancer incidence is rising globally.
  • The skin is constantly exposed to environmental carcinogens like UV radiation.
  • Chemoprevention offers a promising strategy to combat carcinogenesis.

Purpose of the Study:

  • To review the chemopreventive potential of synthetic and natural agents against skin cancer.
  • To explore the mechanisms of action for these agents.
  • To discuss the current status and future prospects of skin cancer chemoprevention.

Main Methods:

  • Review of existing literature on synthetic and natural chemopreventive agents.
  • Analysis of studies in murine skin carcinogenesis models.
  • Evaluation of agents tested in human populations.

Main Results:

  • Numerous synthetic and natural compounds demonstrate chemopreventive effects in preclinical models.
  • A limited number of agents have been evaluated for human efficacy.
  • Many agents are dietary or topically applied for cancer prevention.

Conclusions:

  • Chemoprevention holds significant potential for skin cancer prevention.
  • Dietary and topical agents are being explored for various stages of skin cancer.
  • Further clinical studies are essential to validate these agents for human use.

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