Related Experiment Video
Updated: Jul 7, 2026
07:26
A Simple Method for Automated Solid Phase Extraction of Water Samples for Immunological Analysis of Small Pollutants
Published on: January 1, 2016
Selective solid-phase extraction of bio- and environmental samples using molecularly imprinted polymers.
1Bioanalytical Chemistry, AstraZeneca R&D Södertälje, S-151 85 Södertälje, Sweden. Lars.I.Andersson@astrazeneca.com
Bioseparation
|January 29, 2003
Summary
Molecular imprinting for solid-phase extraction offers high selectivity for routine analysis. This review covers molecular imprinted solid-phase extraction applications and method development for biological and environmental samples.
Area of Science:
- Analytical Chemistry
- Separation Science
Background:
- Molecular imprinting technology offers high selectivity and affinity for specific analytes.
- Solid-phase extraction (SPE) is a widely used technique for sample pre-concentration.
Purpose of the Study:
- To review the applications of molecular imprinting in solid-phase extraction (MI-SPE).
- To discuss method development challenges specific to imprinted sorbents in analytical separations.
Main Methods:
- Literature review of published works on molecular imprinted solid-phase extraction.
- Analysis of selectivity and affinity properties of imprinted sorbents.
Main Results:
- MI-SPE shows significant potential for routine analytical applications.
- Selective pre-concentration of biological and environmental samples using MI-SPE has been demonstrated.
- Imprinting allows for pre-determination of sorbent properties for specific analytes.
Conclusions:
- Molecular imprinted solid-phase extraction is a promising technique for selective and efficient sample preparation.
- Further development in sorbent-specific methods will enhance the routine applicability of MI-SPE.
Related Concept Videos
01:09Ion-Exchange Chromatography
Ion-exchange chromatography, or IEC, is a technique for separating ions based on their affinity for the stationary phase. The stationary phase is a cross-linked polymer resin with covalently attached ionic functional groups. The functional groups can be either positively charged (cation exchangers) or negatively charged (anion exchangers). A cation exchanger consists of a polymeric anion and active cations, while an anion exchanger is a polymeric cation with active anions. The choice of...
01:08Size-Exclusion Chromatography
In size-exclusion chromatography (SEC), also known as molecular-exclusion or gel-permeation chromatography, molecules are separated based on their sizes. This technique is important for separating large molecules such as polymers and biomolecules. The two classes of micron-sized stationary phases encountered in SEC are silica particles and cross-linked polymer resin beads. Both materials are porous, but their pore sizes vary significantly.
Silica particles offer advantages such as rigidity,...
Silica particles offer advantages such as rigidity,...