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Updated: Aug 10, 2026

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
Published on: April 7, 2017
Spindle-cell rhabdomyosarcoma with 2q36 approximately q37 involvement
Maria Debiec-Rychter1, Anne Hagemeijer, Raf Sciot
1Department of Human Genetics, Katholieke Universiteit Leuven, 3000, Leuven, Belgium. maria.debiec-rychter@med.kuleuven.ac.be
Abstract:
The cytogenetic analysis of a spindle-cell variant of embryonal rhabdomyosarcoma (RMS), presenting as a cheek mass in an 18-year-old girl, is reported. The tumor cells showed an abnormal karyotype 46,XX,der(2)t(2;7)(q36 approximately q37;q3?),del(14)(q24),der(16)t(1;16)(q21;q13), with a tetraploid range of chromosome number in a subpopulation of cells. By fluorescence in situ hybridization analysis, the tumor cells were negative for FKHR-disrupting translocations specific for alveolar type of RMS and for NMYC gene amplification.
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